منابع مشابه
Neuromuscular efficacy and histamine-release hemodynamic changes produced by rocuronium versus atracurium: a comparative study.
BACKGROUND Rocuronium and atracurium are muscle relaxants used for short-and intermediate-duration surgical procedures. This study compares rocuronium and atracurium with regard to neuromuscular efficacy, hemodynamic changes, and their effects on plasma histamine concentration. MATERIALS AND METHODS Sixty adult patients scheduled for general surgical operations lasting less than 120 minutes w...
متن کاملAre hypotension and rash after atracurium really caused by histamine release?
A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ascertain whether histamine release caused hemodynamic or cutaneous changes. The treated group of 20 patients was premedicated with the H1 antagonist dimetindene (0.2 mg/kg) and the H2 antagonist ranitidine (1.25 mg/kg); the control group of 20 patients received saline. Six mi...
متن کاملHistamine release during the administration of atracurium or vecuronium in children.
The histamine releasing potential of equivalent bolus doses of atracurium 0.6 mg kg-1 or vecuronium 0.12 mg kg-1 was evaluated in 20 children anaesthetized with halothane. Blood samples were obtained before, and at 2 and 5 min after the administration of the neuromuscular blocker. The twitch response to 0.15 Hz was also evaluated. None of the 10 patients receiving vecuronium had a significant i...
متن کاملThe role of histamine in the cardiovascular effects of atracurium.
We have investigated the effect of a bolus injection of atracurium 0.6 mg kg-1 on the cardiovascular system in 16 patients undergoing aortocoronary bypass surgery. H1- and H2-receptor antagonists were administered to eight patients before the neuromuscular blocker. A standard anaesthetic was used comprising fentanyl, flunitrazepam, etomidate and enflurane. After administration of atracurium, ha...
متن کاملAnaphylatoxin-induced histamine release with human leukocytes: studies of C3a leukocyte binding and histamine release.
Purified human C3a and synthetic COOH-terminal peptides of C3a, i.e., a pentapeptide, Leu-Gly-Leu-Ala-Arg (5R), and an octapeptide, Ala-Ala-Ala-Leu-Gly-Leu-Ala-Arg (8R) induced histamine release from human basophil granulocytes. On a molar basis, 5R was one-tenth and 8R was one-fifth as active as C3a in causing histamine release. It was found that 125I-C3a binds to whole leukocytes, interacting...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1986
ISSN: 0007-0912
DOI: 10.1093/bja/58.suppl_1.19s